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Participation in a needle-exchange program is considered the best recommendation for a patient using injectable illegal drugs to prevent AIDS because it directly addresses the primary risk factor for HIV transmission in this population: sharing needles. Needle-exchange programs provide a safe and hygienic way to obtain sterile needles, significantly reducing the risk of transmitting HIV and other bloodborne pathogens among individuals who inject drugs.

These programs not only distribute clean syringes but also often provide access to other vital health services, including educational resources about safe drug use practices, testing for HIV and other infectious diseases, and treatment options for those interested in reducing or quitting drug use. By using sterile needles obtained from these programs, individuals can substantially lower their risk of HIV infection and contribute to public health efforts aimed at reducing the spread of the virus.

Other options may suggest important practices, but they do not have the same comprehensive impact on reducing transmission risk as participating in a needle-exchange program. For example, while avoiding sexual intercourse or cleaning injection equipment can be beneficial, they do not directly address the primary transmission route. Asking others to get tested provides useful information but fails to ensure immediate protection against HIV transmission.